簡要描述:Pseudouridine-5'-Triphosphate室用于RNA合成的新產(chǎn)品,主要用于干細(xì)胞研究用
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Pseudouridine-5'-Triphosphate室用于RNA合成的新產(chǎn)品,主要用于干細(xì)胞研究用
Reference(s) | ||||
Anderson, B.R., Muramatsu, H., Jha, B.K., Silverman, R.H., Weissman, D., Kariko, K. Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L (2011) Nucleic Acids Research, EPub Aug | ||||
Kariko K, Muramatsu H, Ludwig J, Weissman D. Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein encoding mRNA. (2011) Nucleic Acids Research. | ||||
Anderson, B., Muramatsu, H., Nallagatla, S.R., Bevilacqua, P.C., Sansing, L.H., Weissman, D. & Kariko, K. Incorporation of pseudouridine into mRNA enhances translation by dimishing PKR activation (2010) Nucleic Acids Research, 38(17): 5884-5892. | ||||
Warren et al., Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA, Cell Stem Cell (2010), doi:10.1016/j.stem.2010.08.012. | ||||
Kariko K, Muramatsu H, Welsh F, et al. Incorporation of Pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. (2008) Molecular Therapy (16)11: 1833-1840. | ||||
Belliot G, Sosnovtcev SV, Chang KO, Babu V, Uche U, Arnold JJ, Cameron CE, Green KY. Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. (2005) Journal of Virology, 79(4): 2393-2403. | ||||
Kariko, K., Buckstein, M., Ni, H. & Weissman, D. Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modifiation and the Evolutionary Origin of RNA (2005). Immunity, 23(2), 165-175. | ||||
Madore E, Florentz C, Giege R, Sekine S, Yokoyama S, Lapointe J. Effect of modified nucleotides on Escherichia coli tRNAGlu structure and on its aminoacylation by glutamyl-tRNA synthetase. Predominant and distinct roles of the mnm5 and s2 modifications of | ||||
Goldberg IH, Rabinowitz M. Comparative utilization of pseudouridine triphosphate and uridine triphosphate by ribonucleic acid polymerase. (1963) J. Biol. Chem., 238(5): 1793-1800. |
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